Not sure if anybody has pointed this out yet, but I found it incredibly useful, so I thought I'd share my knowledge.
I noticed a few weeks ago that I could run while casting Lightning Bolt. How does this help?
Well, when soloing I can gain extra distance between the mob and myself while i wait for my most powerful spells to cool down and not letting him hit me. It is especially effective when used like this:
Ice Bolt/Blast > MM(max) > Fire Bolt(max) > Lightning Bolt (while running backwards) > MM(max) > etc. (whatever spells you have)
The trick is to start running backwards as soon as you throw the fire bolt. Then at any time you can hit Lightning Bolt. Keep running unitl your MM cools down and then start up with the rest of your spells!
If you hit with your Ice this becomes even more effective.