Missle[01] combo is probably for bosses. Another combo that I use it using Firebolt[01] with 3 skill empowerment in decrease cool down time.
Firebolt[01]->M Missle[01]->Lightning->Missle->Fire->Ice->Missle->Fire->Missle->run around till Missle appears->Fire->Repeat with other bolts
This helps a lot in Boss battles since it's almost an unlimited combo of magic
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