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No, I would strongly advise against empowering the damage of any of your AoE spells. Inferno's damage can't be empowered anyways but if you try and empower the damage on Frost Nova, you'll be wasting five points. I tried it once to test it out and there was almost no visible change in damage. And don't bother empowering Magic Burst. You get a fourth AoE spell at level 120 or around there that you'll probably need to save five points for.
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