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The biggest downside to a pure build of any kind is that you'll always lack something. Pure DEX would be theoretically great in PvE but what if you're a heavy PvP-er? You'll go in, someone with a tier 2/3 power scroll will wipe you out almost instantly. Even if you get some great END gear and enhance it, you'll still suffer greatly in that area. Other than that, a pure DEX build might be perfect for grinding, questing, etc.
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