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When i'm fighting bosses i generally go with the following...
MM(Max) then ICE(Max) then wait a few secs for MM to cool then...
MM(Max) then FIRE(Max) then wait another few seconds, then...
MM(Max) then LIGHTNING(Max) then another few seconds for MM to cool... then repeat.
Your longest cooldown is 15sec and Magic Missle cools in 4 seconds, so by the time you get into the groove of the pattern, you only have 15 - 12 = 3 seconds of non-spell casting time per 15 seconds which you can distribute out evenly or use to chat while you're killing. Rounding down damage for a boss like the Cave Marlone (at level 25 or so) is about 100 dmg per spell. So you damage per second (DPS) works out to be a steady 100 damage per second for as long as you have the SP for it. Not too shabby!
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