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You should generally customize your button spread so that your most frequently used skills are nearest to WASD, even if you use your mouse to move, as the "base" position of your hands on your keyboard is on the ASDFJKL; keys.
For example, I have:
1 = Item Pickup
2 = Bash
3 = Heal
4 = Rejuvenate
5 = Trip
6 = Recover
As those 5 skills and that action are most common for me, I have them closest together to make it easier to access those skills.
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